BDR Special Issue

Designing Proteins With New Folds and Function: Where Do We Stand and What Have We Learned?

Banner graphic of proteins

The Science Partner Journal BioDesign Research is now considering submissions for its second special issue: Designing Proteins With New Folds and Function: Where Do We Stand and What Have We Learned?


The rational design of proteins, once considered a myth, is becoming a reality as efforts to produce proteins with desired functional properties and different folds, including new ones, have been increasingly successful. The goal of this special issue is to provide an overview of the various factors and adjacent areas of science contributing to these advancements, to yield insights on the lessons learned from the successes and failures along the way and assess where the field stands today and the promise it holds for the future.

Contributions on the following topics will be welcome:

  1. De-novo design of soluble proteins with novel folds and function
  2. De-novo design or re-design of membrane-bound proteins
  3. Re-design of natural proteins for novel applications
  4. Computational approaches including AI-Deep Learning methods to rational protein design
  5. Evolutionary approaches to rational protein design
  6. Design of enzymes with novel catalytic function
  7. Design of protein segments and peptides with specific functions
  8. Rational design of protein assemblies and nanomaterials
  9. Design of protein using minimalist sequences

Both research articles and reviews dealing with these topics will be considered. Authors wishing to submit a review are invited to first inquire with the Special Issue Editor (Shoshana Wodak:

Articles published in the special issue will be highlighted at the annual International BioDesign Research Conference, held every fall. The 1st International BioDesign Research Conference was held virtually in December 2020; this successful conference attracted more than 20,000 registrants and featured more than 60 world-renowned experts.

    Submission Deadline Extended

    Submissions are open now and will close December 31, 2022. All submitted papers will be peer reviewed and published after acceptance. All article processing charges (APCs) for papers will be waived. Published papers will be collectively placed in a virtual special issue.

      Submission Instructions

      Visit the Author Guidelines for full details. When submitting, please select the special issue topic as the Section/Category and indicate in your cover letter that your submission is intended for inclusion in the Protein Design special issue, ensuring to also address your letter to the attention of the Editor of the Special Issue (Shoshana Wodak). For more specific information please contact

      Table of Contents

      As articles within the special issue are published they will appear below.

      De Novo Design of a Highly Stable Ovoid TIM Barrel: Altering Pocket Shape Towards Functional Design

      Alexander E. Chu, Daniel Fernandez, Jingjia Liu, Raphael R. Eguchi, and Po-Ssu Huang

      BioDesign Research, Vol. 2022, Article ID 9842315 | In Press

      An Overview of Antiviral Peptides and Rational Biodesign Considerations

      Ying-Chiang J. Lee, Jaden D. Shirkey, Jongbeom Park, Karishma Bisht, and Alexis J. Cowan

      BioDesign Research, Vol. 2022, Article ID 9898241 | May 17, 2022

      Design of Protein Segments and Peptides for Binding to Protein Targets

      Suchetana Gupta, Noora Azadvari, and Parisa Hosseinzadeh

      BioDesign Research, Vol. 2022, Article ID 9783197, 25 pages | Apr 16, 2022

      Dawn of a New Era for Membrane Protein Design

      Shahin Sowlati-Hashjin, Aanshi Gandhi, and Michael Garton

      BioDesign Research, Vol. 2022, Article ID 9791435, 17 pages | Apr 15, 2022

      What Have We Learned from Design of Function in Large Proteins?

      Olga Khersonsky and Sarel J. Fleishman

      BioDesign Research, Vol. 2022, Article ID 9787581, 11 pages | Mar 8, 2022