Advanced Ultrasound Technologies and Biomedical Applications

SI banner


Ultrasound is a non-invasive imaging technology that is widely used for examination in clinical medicine and also as an important tool for research. Diagnostic ultrasound as well as ultrasound guidance for biopsy and tumor ablation have become integral in clinical instrumentation. Recently, there has been an increase in new ultrasound techniques such as high-resolution contrast enhanced ultrasound, micro-elastography techniques, 3D ultrasound, plane wave imaging, high frequency ultrasound, and ultrasound modulation. In addition, therapeutic ultrasound, such as high intensity focused ultrasound (HIFU), histotripsy, ultrasound drug delivery, ultrasound-enhanced immunotherapy, sonothrombolysis, and ultrasound neuromodulation, has made significant progress technically, scientifically, and clinically. This special issue invites submissions of both original research and review papers covering advanced ultrasound technologies within all aspects of advanced ultrasound.

  • The topics we specifically seek to cover include (but are not limited to):
  • 3D ultrasound
  • Blood flow Imaging
  • Contrast enhanced ultrasound
  • Elasticity imaging 
  • HIFU technology
  • High frequency ultrasound
  • Histotripsy
  • Novel ultrasound transducer/arrays
  • Plane wave imaging
  • Sonothrombolysis
  • Ultrasound drug delivery
  • Ultrasound modulation
  • Ultrasound-enhanced immunotherapy

    Guest Editors

    Qifa Zhou, University of Southern California
    Zhen Xu, University of Michigan
    Joo Ha Hwang, Stanford University
    K Kirk Shung, University of Southern California

      Table of Contents

      As articles within the special issue are published they will appear below.

      Particle-Mediated Histotripsy for the Targeted Treatment of Intraluminal Biofilms in Catheter-Based Medical Devices

      Christopher Childers, Connor Edsall, Isabelle Mehochko, Waleed Mustafa, Yasemin Yuksel Durmaz, Alexander L. Klibanov, Jayasimha Rao, Eli Vlaisavljevich

      BME Frontiers, vol. 2022, Article ID 9826279, 14 pages, 2022

      Noninvasive Low-Intensity Focused Ultrasound Mediates Tissue Protection following Ischemic Stroke

      Alexandra M. Kaloss, Lauren N. Arnold, Eman Soliman, Maya Langman, Nathalie Groot, Eli Vlaisavljevich, Michelle H. Theus

      BME Frontiers, vol. 2022, Article ID 9864910, 11 pages, 2022

      High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

      Qiangzhou Rong, Youngseop Lee, Yuqi Tang, Tri Vu, Carlos Taboada, Wenhan Zheng, Jun Xia, David A. Czaplewski, Hao F. Zhang, Cheng Sun, Junjie Yao

      BME Frontiers, vol. 2022, Article ID 9891510, 8 pages, 2022

      Three-Dimensional Shear Wave Elastography Using a 2D Row Column Addressing (RCA) Array

      Zhijie Dong, Jihun Kim, Chengwu Huang, Matthew R. Lowerison, U-Wai Lok, Shigao Chen, Pengfei Song

      BME Frontiers, vol. 2022, Article ID 9879632, 11 pages, 2022

      A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging

      Haoyang Chen, Sumit Agrawal, Mohamed Osman, Josiah Minotto, Shubham Mirg, Jinyun Liu, Ajay Dangi, Quyen Tran, Thomas Jackson, Sri-Rajasekhar Kothapalli

      BME Frontiers, vol. 2022, Article ID 9871098, 14 pages, 2022

      Highly Integrated Multiplexing and Buffering Electronics for Large Aperture Ultrasonic Arrays

      Robert Wodnicki, Haochen Kang, Di Li, Douglas N. Stephens, Hayong Jung, Yizhe Sun, Ruimin Chen, Lai-Ming Jiang, Nestor E. Cabrera-Munoz, Josquin Foiret, Qifa Zhou, Katherine W. Ferrara

      BME Frontiers, vol. 2022, Article ID 9870386, 22 pages, 2022

      Development of Moderate Intensity Focused Ultrasound (MIFU) for Ocular Drug Delivery

      Alejandra Gonzalez-Calle, Runze Li, Isaac Asante, Juan Carlos Martinez-Camarillo, Stan Louie, Qifa Zhou, Mark S. Humayun

      BME Frontiers, vol. 2022, Article ID 9840678, 8 pages, 2022

      A Review of Imaging Methods to Assess Ultrasound-Mediated Ablation

      Brett Z. Fite, James Wang, Pejman Ghanouni, Katherine W. Ferrara

      BME Frontiers, vol. 2022, Article ID 9758652, 17 pages, 2022

      Blood-Brain Barrier Opening by Individualized Closed-Loop Feedback Control of Focused Ultrasound

      Chih-Yen Chien, Yaoheng Yang, Yan Gong, Yimei Yue, Hong Chen

      BME Frontiers, vol. 2022, Article ID 9867230, 11 pages, 2022

      Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution

      Xuejun Qian, Gengxi Lu, Biju B. Thomas, Runze Li, Xiaoyang Chen, K. Kirk Shung, Mark Humayun, Qifa Zhou 

      BME Frontiers, vol. 2022, Article ID 9829316, 13 pages, 2022

      Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors

      Juan Tu, Alfred C. H. Yu

      BME Frontiers, vol. 2022, Article ID 9807347, 17 pages, 2022.