BioDesign Research / 2021 / Article / Fig 2

Research Article

In-Depth Computational Analysis of Natural and Artificial Carbon Fixation Pathways

Figure 2

Overview of natural occurring and artificial CO2- and C1-fixing pathways that were integrated in the model. For simplification, reaction arrows can include multiple reactions and skip some metabolites. ADP, AMP, phosphate, water, and oxidized forms of electron carriers were also left out to improve clarity. Primary products of the pathways are underlined. Abbreviations: Ac-CoA: acetyl-CoA; Prop-CoA: propanoyl-CoA; β-MM-CoA: β-methylmalyl-CoA; CitMal-CoA: citramalyl-CoA; Pyr: pyruvate; MM-CoA: methylmalonyl-CoA; Succ-CoA: succinyl-CoA; Glyox: glyoxylate; 4HB-CoA: 4-hydroxybutyrate; AcAc-CoA: acetoacetyl-CoA; R15P: ribulose-1,5-bisphosphate; 3PG: 3-phosphoglycerate; 13BPG: 1,3-bisphophoglycerate; GAP: glyceraldehyde-3-phosphate; R5P: ribulose-5-phosphate; H6P: hexulose-6-phosphate; MSAld: malonate semialdehyde; Ala: alanine; β-Ala: β-alanine; Oxaloac: oxaloacetate; 6-PG: 6-phosphoglycerate; OH-Pyr: hydroxypyruvate; 2-PG: 2-phosphoglycerate; 10-CHO-THF: 10-formyltetrahydrofolate; CH2-THF: 5,10-methylenetetrahydrofolate; LP-S2: [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine; LP-S-CH2NH2: [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine; LP-SH: [glycine-cleavage complex H protein]-dihydrolipoyl-L-lysine.