BioDesign Research / 2022 / Article / Fig 10

Review Article

Design of Protein Segments and Peptides for Binding to Protein Targets

Figure 10

General schematic for prediction of cell penetration potency of given peptidic sequences. The prediction algorithm considers an input sequence of the peptide of interest. Various features like amino acid composition, number of rotatable bonds, hydrogen bonds, torsions, and others are extracted from the sequence to train the prediction model (SVM, random forest, Gaussian process classifier, among others). The model then predicts the cell penetrating potency of the input sequence.