BioDesign Research / 2022 / Article / Fig 2

Review Article

Design of Protein Segments and Peptides for Binding to Protein Targets

Figure 2

Schematic representation of different methods used for designing peptide binders. To obtain a peptide that binds to a surface of interest (shown in spheres within the circle in the top-left figure. Structure from PDB ID: 6WSJ), researchers can take on three general approaches: (1) structure-guided design, which uses natural motifs as a starting point to create the binders, (2) de novo design, which builds many potential peptide binders from scratch and ranks them to select the best candidates for testing, and (3) learning-based design, which takes advantage of machine learning and deep-learning methods to learn from available data and create peptide binders.