BioDesign Research / 2022 / Article / Fig 5

Review Article

Design of Protein Segments and Peptides for Binding to Protein Targets

Figure 5

General overview of de novo design methods that sample the sequence space. The design process starts with a diversification step where a pool of sequences is generated. These sequences then go through a structural modeling step where they can be ranked. The different sizes in the right panel are proportional to the rank (the best model is the biggest). The best ranking sequences are then tested or fed as the initial sequence for another round of design.