BioDesign Research / 2022 / Article / Fig 6

Review Article

Design of Protein Segments and Peptides for Binding to Protein Targets

Figure 6

Schematic representation of sense-antisense amino acid pairing theory. The overall hypothesis behind this theory is that when choosing amino acids to bind to a target surface, amino acids that are antisense of those at the interface tend to bind with higher affinity than randomly selected amino acids. Whether two amino acids are sense-antisense is determined from their tRNA codons as shown in the figure.