BioDesign Research / 2022 / Article / Fig 7

Review Article

Design of Protein Segments and Peptides for Binding to Protein Targets

Figure 7

Helical motifs are prevalent at protein-protein interfaces. Examples of helix-mediating protein-protein interactions are shown. The sticks show hot spot residues that make a major contribution to binding. The boxes at the bottom row are zoomed views of the hot-spot residues at the binding interface (boxed regions in the overall figures shown in the top row). The helices are shown as transparent cartoons in the bottom panel for clarity.