BioDesign Research / 2022 / Article / Fig 8

Review Article

Design of Protein Segments and Peptides for Binding to Protein Targets

Figure 8

A schematic overview of sampling cyclic peptides with generalized kinematic loop closure. In the first step, the torsional degrees of freedom of all but three residues (pivots) are randomly sampled. In the second step, the torsion angles of pivots are calculated to find a closed solution. The anchor position will remain unchanged.