BME Frontiers / 2020 / Article / Fig 1

Research Article

Effects of Histotripsy on Local Tumor Progression in an in vivo Orthotopic Rodent Liver Tumor Model

Figure 1

Histotripsy tumor response and survival outcomes. (a) Local tumor regression was observed in 9/9 complete ablation cases and 5/6 partial ablation cases irrespective of large tumor volume (>200 mm3) or small tumor volume (<200mm3) as measured at the pretreatment timepoint (week 0). In contrast, 3/6 control animals demonstrated steady tumor progression while the other 3/6 control animals demonstrated spontaneous regression of their tumors. Individually scaled -axes are used to more clearly illustrate changes in tumor size. (b) Kaplan Meier survival curve comparing survival outcomes in the control, partially ablated, and completely ablated groups. All animals still surviving at 12 weeks were euthanized due to reaching the study endpoint (3 months) in the protocol.

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