Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors
Membrane perforation and recovery dynamics in single-site sonoporation. (a) Diagram of the acoustically coupled confocal microscopy platform used for this investigation. (b) Representative sonoporation site images from perforation to recovery. (c, d) Temporal peak pore diameter and area for sonoporation sites that resealed successfully and unsuccessfully (;). (e) Characteristic time for perforation and recovery for the 7 successfully resealed sonoporation sites (), referenced to literature .