BME Frontiers / 2022 / Article / Fig 2

Review Article

Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors

Figure 2

Bleb emerges at the sonoporation site. (a, b) 3D confocal imaging of plasma membrane (orange; maximum intensity projection shown on three planes). Two cells are shown: (left) an unsonoporated cell; (right) a cell sonoporated by ultrasound-triggered microbubble collapse. Sytox blue was used as sonoporation tracer (giving pink cytoplasmic fluorescence when merged with orange membrane). (c) Volumetric rendering of membrane bleb (top-down view), referenced to literature [78].