Cyborg and Bionic Systems / 2021 / Article / Fig 1

Research Article

Bioprinted Vascularized Mature Adipose Tissue with Collagen Microfibers for Soft Tissue Regeneration

Figure 1

Patterning bioprinting on a surface and bioprinting in a supporting bath for 3D vascularized adipose tissue reconstruction. The same mixture containing the three types of cells (human mature adipocytes, HUVEC, and human adipose-derived stem cells) embedded in a fibrin gel including collagen microfibers (CMF) can be bioprinted using a mechanical extrusion dispenser bioprinter either as a pattern on the bottom surface of a dish (a) or inside a supporting bath made of gellan gum (GG) (b). After gelation, the two bioprinted tissues were cultured for 7 days to enable the reconstruction of in vitro vascularized adipose tissue.