Health Data Science / 2021 / Article / Tab 1

Research Article

Machine Learning Highlights Downtrending of COVID-19 Patients with a Distinct Laboratory Profile

Table 1

Demographic information of the patient cohort and comparison of 21 laboratory tests in SARS-CoV-2 positive and negative patients.

Feature name value value (Bonferroni correction) value (demographics adjustment)Total patientsPositive patients ()Negative patients ()

Male
(%)
1.35e-15--2,415 (48.62%)748 (30.97%)1,667 (69.03%)
Female
(%)
---2,552 (51.38%)537 (21.04%)2,015 (78.96%)
Age
Mean (SD)
3.53e-17--58.33 (20.36)62.61 (17.61)56.83 (21.03)
Race: Black or African American
(%)
0.05 (White vs. Black)--530 (10.67%)122 (23.02%)408 (76.98%)
Race: Asian---240 (4.83%)49 (20.42%)191 (79.58%)
Race: Caucasian---1,691 (34.04%)321 (18.98%)1,370 (81.02%)
Race: other---2,506 (50.45%)793 (31.64%)1,713 (68.36%)

Anion gap
Median (25%-75% quantile)
7.80e-272.11e-258.45e-169.0 (7.7, 11.0)9.5 (8.5, 11.0)9.0 (7.5, 10.5)
Albumin (g/dL)1.31e-893.53e-881.94e-683.4 (2.9, 3.9)3.0 (2.7, 3.5)3.6 (3.0, 4.1)
Alkaline phosphatase (U/L)1.37e-093.69e-082.11e-0279.0 (63.0, 107.0)75.0 (58.5, 102.0)80.5 (65.0, 108.5)
Indirect bilirubin (mg/dL)2.35e-396.33e-385.79e-120.4 (0.3, 0.5)0.3 (0.2, 0.4)0.4 (0.3, 0.6)
Calcium (mg/dL)1.94e-1565.25e-1552.92e-1239.0 (8.5, 9.5)8.5 (8.1, 9.0)9.15 (8.7, 9.6)
Chloride (mmol/L)1.41e-323.80e-317.16e-17103.5 (100.7, 106.0)102.0 (99.0, 105.0)104.0 (101.0, 106.0)
Globulin (g/dL)1.75e-504.73e-493.45e-273.1 (2.8, 3.6)3.4 (3.0, 3.7)3.1 (2.7, 3.5)
Glucose (mg/dL)2.52e-146.79e-137.73e-07108.7 (95.5, 131.0)113.0 (98.0, 141.4)107.0 (95.0, 128.7)
Sodium (mmol/L)1.44e-373.88e-361.55e-18139.0 (137.0, 141.0)138.0 (135.5, 140.3)139.5 (137.5, 141.1)
Total protein (g/dL)1.59e-164.29e-155.02e-116.6 (6.1, 7.1)6.5 (6.0, 6.9)6.7 (6.2, 7.2)
Basophil percentage5.91e-601.60e-587.27e-310.45% (0.30%, 0.70%)0.30% (0.20%, 0.50%)0.50% (0.30%, 0.70%)
Hematocrit1.07e-122.88e-115.33e-1137.85% (33.49%, 41.42%)38.6% (35.15%, 42.10%)37.54% (32.86%, 41.20%)
Hemoglobin (g/dL)1.79e-164.83e-157.50e-1512.6 (11.0, 13.9)12.9 (11.6, 14.2)12.4 (10.8, 13.8)
White blood cell (WBC) (×10(3)/μL)2.97e-288.02e-275.54e-037.90 (5.90, 10.60)6.92 (5.10, 9.55)8.10 (6.20, 10.9)
Lymphocyte count (×10(3)/μL)2.43e-696.56e-683.17e-041.20 (0.78, 1.75)0.90 (0.60, 1.25)1.31 (0.86, 1.90)
Mean corpuscular volume (MCV, fL)4.13e-071.12e-056.13e-0789.7 (85.7, 93.5)89.0 (85.1, 92.5)90.0 (85.9, 93.9)
Monocyte count (×10(3)/μL)3.34e-379.02e-368.96e-250.6 (0.4, 0.8)0.5 (0.4, 0.7)0.6 (0.5, 0.8)
Neutrophil count (×10(3)/μL)1.37e-063.70e-051.37e-055.4 (3.7, 8.0)5.1 (3.4, 7.5)5.5 (3.8, 8.2)
Red blood cell count (×10(6)/μL)4.50e-191.22e-172.73e-174.24 (3.72, 4.69)4.41 (3.92, 4.79)4.19 (3.66, 4.66)
Red blood cell distribution width (RDW-CV)3.74e-071.01e-055.39e-1214.3% (13.4%, 15.8%)14.0% (13.4%, 15.2%)14.3% (13.4%, 16.0%)
Magnesium (mg/dL)1.43e-043.87e-035.80e-031.97 (1.80, 2.11)2.00 (1.80, 2.20)1.95 (1.80, 2.10)