Research / 2018 / Article / Fig 1

Research Article

A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization

Figure 1

Schematic illustration for the metal-free click bioconjugation with native groups of biotargets based on activated alkynes. Native functional groups, including amine, thiol, and hydroxyl groups in different targets at diverse levels are employed to achieve on-demand modification of natural/synthetic polymers, peptide, protein, rapid whole cell mapping, and specific staining of Gram-positive bacteria.