Research / 2019 / Article / Fig 1

Research Article

Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse

Figure 1

Experimental design and UDBS targets. (a) Timeline of the experiment; MPTP was administrated from day 1 to 5 and UDBS stimulation was delivered from day 6 to 12. Rotarod performance was assessed on day 6, 9, and 12. Pole test was performed on day 6 and 12, and the open field test was conducted on day 12. (b) The wearable ultrasound for deep brain stimulation of the STN (c) or GP (d). Acoustic intensity distributions in the longitudinal plane without mouse skull (e) and with mouse skull (f). (g) Schematic of UDBS parameters with 1 kHz pulse repetition frequency (PRF) and 50% duty cycle (DC).