Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse
Neuroprotective effects of STN-UDBS or GP-UDBS. (a) Immunohistochemistrical staining for TH positive neurons in the left SNpc. (b) The number of TH positive neurons in the left SNpc is significantly decreased in group II compared with group I and significantly increased in groups III and IV compared with group II. (c) Western blot analysis of TH protein level in the left SN. TH protein level decreases after MPTP injection and UDBS increases TH protein level in group III and IV compared with group II (group I: control-sham, group II: MPTP-sham, group III: MPTP-STN-UDBS and group IV: MPTP-GP-UDBS; one–way ANOVA with Tukey’s post hoc: p < 0.05, p < 0.01, p < 0.001, mean ± SEM, n = 5 per group in (a), n = 4 per group in (c)).