Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties
GMVs as packaging of therapeutic drugs for drug delivery. Flow cytometry of GMVs loaded with curcumin (a). Cell viability of HeLa cells incubated with GMVs loaded with curcumin (0.5 μg mL−1) for 48 h (b). Cell viability of CCRF-CEM cells incubated with GMVs loaded with curcumin (4 μg mL−1) for 24 h (c). About 10000 events were counted for each sample. Scale bar is 10 μm. The statistical significance of the observed differences was analyzed by t tests. Statistical significance was set at p < 0.05 (P < 0.05, P < 0.01).