The structure of teixobactin and its performance against pathogenic microorganisms. (a) Schematic structure of teixobactin. (b) Activity of teixobactin against pathogenic microorganisms. (c) Time-dependent killing of pathogens by teixobactin. S. aureus
grew to early (upper left) and late (upper right) exponential phase and challenged with antibiotics. Teixobactin treatment resulted in lysis (lower left) and resistance acquisition during serial passaging in the presence of sub-MIC levels of antimicrobials (bottom lower right). The -
axis is the highest concentration the cells grew during passaging [126
]. Copyright © 2020, Springer Nature.