Darobactin produced by a silent operon of P. khanii
is a bactericidal antibiotic. (a) Darobactin structure. (b) Time-dependent killing of E. coli
MG1655 by darobactin. An exponential culture of E. coli
MG1655 was challenged with 16x MIC antibiotics. (c) Schematic of the Bam complex. IM: inner membrane; OM: outer membrane. (d) Scanning electron microscopy analysis of E. coli
MG1655 treated with 16x MIC darobactin. Scale bars, 1 μ
]. Copyright © 2020, Springer Nature.