The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

<div class="floats-full-page floats-full-page-figure"><h2>Figure 2</h2><div class="floats-full-page-caption"><div>Darobactin produced by a silent operon of <i>P. khanii</i> is a bactericidal antibiotic. (a) Darobactin structure. (b) Time-dependent killing of <i>E. coli</i> MG1655 by darobactin. An exponential culture of <i>E. coli</i> MG1655 was challenged with 16x MIC antibiotics. (c) Schematic of the Bam complex. IM: inner membrane; OM: outer membrane. (d) Scanning electron microscopy analysis of <i>E. coli</i> MG1655 treated with 16x MIC darobactin. Scale bars, 1 <i>μ</i>m [<a href="../../2016201/#B127">127</a>]. <i>Copyright © 2020, Springer Nature.</i></div></div><div class="floats-full-page-content"><table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://d31iiq90dwlpfy.cloudfront.net/articles/research/volume-2020/2016201/figures/2016201.fig.002a.svgz" name="2016201.fig.002a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b></td></tr><tr class="fig-image" id="b"><td><object data="https://d31iiq90dwlpfy.cloudfront.net/articles/research/volume-2020/2016201/figures/2016201.fig.002b.svgz" name="2016201.fig.002b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b></td></tr><tr class="fig-image" id="c"><td><object data="https://d31iiq90dwlpfy.cloudfront.net/articles/research/volume-2020/2016201/figures/2016201.fig.002c.svgz" name="2016201.fig.002c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b></td></tr><tr class="fig-image" id="d"><td><object data="https://d31iiq90dwlpfy.cloudfront.net/articles/research/volume-2020/2016201/figures/2016201.fig.002d.svgz" name="2016201.fig.002d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(d) </b></td></tr></table></div></div>

Figure 2 | The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

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Figure 2: The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

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Figure 2

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<p>The open access journal <em>Research</em>, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.</p>


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<p><em>Research's</em>&nbsp;Editorial Board includes international experts in fields ranging from life sciences to physical sciences. Tianhong Cui of University of Minnesota and Weimin Bao of China Association for Science and Technology serve as the Editors-in-Chief of the journal.</p>


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The open access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.