Research / 2020 / Article / Fig 2

Review Article

The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

Figure 2

Darobactin produced by a silent operon of P. khanii is a bactericidal antibiotic. (a) Darobactin structure. (b) Time-dependent killing of E. coli MG1655 by darobactin. An exponential culture of E. coli MG1655 was challenged with 16x MIC antibiotics. (c) Schematic of the Bam complex. IM: inner membrane; OM: outer membrane. (d) Scanning electron microscopy analysis of E. coli MG1655 treated with 16x MIC darobactin. Scale bars, 1 μm [127]. Copyright © 2020, Springer Nature.