The structures of the chimeric polymyxin B1 and their mechanism studies using fluorescence and transmission electron microscopy. (a) The structures of chimeric polymyxin B1. (b) Fluorescence microscopy of E. coli
ATCC 25922 cells grown in MH-II and stained with FM4-64, DAPI, or SYTOX-green, without treatment. (c) Transmission electron microscopy of E. coli
ATCC 25922 untreated or grown with 3 or 4 at concentrations causing about 50% growth inhibition (about 0.1 mg L−1
biologically independent experiments). Scale bars, 200 nm [128
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