Research / 2020 / Article / Fig 5

Review Article

The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

Figure 5

The schematic structure and antibacterial efficacy of targeted antibiotic-loaded nanoparticles. (a) A schematic illustration of the therapeutic nanoparticle system consisting of pSiNP, chemotherapeutic agent, and homing peptide. (b) The CARG peptide shows selective binding to cultured S. aureus in vitro and homes to infected lungs in vivo. (c) The CARG does not recognize cultured Pseudomonas aeruginosa bacteria or lung tissue infected with these bacteria. (d) Biodistribution of nanoparticles obtained from the luminescence intensity in each organ. (e) Survival rate () of mice after intratracheal inoculation with colony-forming units (CFU) of S. aureus [224]. Copyright © 2018, Springer Nature.