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Research Article

Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis

Table 1

Characteristics of the 34 studies included in the meta-analysis.

First author, source, yearPatient geographic locationTotal casesAge in years, or median (range)COVID-19 severityExtracted disease comorbidity
ICU and/or severe/ARDS COVID-19, (%)Non-ICU and/or nonsevere COVID-19, (%)

Cao M, medRxiv, 2020 [2]Shanghai19819 (9.6%)179 (90.4%)Hypertension, CVD, diabetes
Chen C, Zhonghua Xin Xue Guan Bing Za Zhi, 2020 [81]Wuhan15024 (16.0%)126 (84.0%)Hypertension, CVD, diabetes
Chen G, J Clin Invest, 2020 [82]Wuhan2156 (50-65)11 (52.4%)10 (47.6%)Hypertension, diabetes
Chen X, medRxiv, 2020 [3]Changsha29146 (34-59)50 (17.2%)241 (82.8%)Hypertension, CVD, CKD, CLD, diabetes
Chen XH, medRxiv, 2020 [4]Wuhan4827 (56.3%)21 (43.7%)Hypertension, CVD, CLD, diabetes
Fan L, medRxiv, 2020 [83]Shenyang5546.88 (14.5%)47 (85.5%)CVD, diabetes
Feng Z, medRxiv, 2020 [84]Changsha14144 (34-55)15 (10.6%)126 (89.4%)Hypertension, CVD, diabetes
Guan W, N Engl J Med, 2020 [13]National1,09947 (35-58)173 (16.0%)926 (84.0%)Hypertension, CVD, CKD, CLD, diabetes
Hu L, medRxiv, 2020 [85]Wuhan32361 (23-91)172 (53.3%)151 (46.7%)Hypertension, CVD, CKD, CLD, diabetes
Huang C, Lancet, 2020 [5]Wuhan4149 (41-58)13 (32.0%)28 (68.0%)Hypertension, CVD, diabetes
Huang H, medRxiv, 2020 [86]Guangzhou12532 (25.6%)93 (74.4%)Hypertension, diabetes
Li KH, Invest Radiol, 2020 [87]Chongqing8325 (30.1%)58 (69.9%)Hypertension
Li Y, Curr Med Sci, 2020 [88]Wuhan25NA9 (36.0%)16 (64.0%)Hypertension, CVD
Liu J, medRxiv, 2020 [15]Wuhan4013 (33.0%)27 (68.0%)Hypertension, diabetes
Liu JY, medRxiv, 2020 [89]Beijing6140 (1-86)17 (28.0%)44 (72.0%)Hypertension, diabetes
Liu L, medRxiv, 2020 [90]Chongqing5145 (34-51)7 (13.7%)44 (86.3%)Hypertension
Liu W, Chin med J (Engl), 2020 [91]Wuhan7838 (33-57)11 (14.1%)67 (85.9%)Hypertension, diabetes
Liu Y, medRxiv, 2020 [92]Wuhan10955 (43-66)53 (48.6%)56 (51.4%)Hypertension, CVD, CKD, diabetes
Lu H, medRxiv, 2020 [16]Shanghai265NA22 (8.3%)243 (91.7%)Hypertension, CVD, CKD, diabetes
Mao L, medRxiv, 2020 [93]Wuhan21488 (41.1%)126 (58.9%)Hypertension, CKD, diabetes
Qi D, medRxiv, 2020 [94]Chongqing26748 (20-80)50 (18.7%)217 (81.3%)Hypertension, diabetes
Qin C, Clin Infect Dis, 2020 [95]Wuhan45258 (47-67)286 (63.3%)166 (36.7%)Hypertension, CVD, CKD, CLD, diabetes
Shi Y, Crit Care, 2020 [96]Zhejiang48749 (10.1%)438 (89.9%)Hypertension, CVD, CKD, CLD, diabetes
Wan S, J Med Viro, 2020 [97]Chongqing13547 (36-55)40 (29.6%)95 (70.4%)Hypertension, CVD, CLD, diabetes
Wang D, JAMA, 2020 [6]Wuhan13856 (42-68)36 (26.0%)102 (74.0%)Hypertension, CVD, CKD, diabetes
Wang L, Am J Nephrol, 2020 [98]Wuhan11654 (38-69)57 (49.1%)59 (50.9%)Hypertension, CKD, diabetes
Wang YF, medRxiv, 2020 [99]Wuhan110NA38 (34.5%)72 (65.5%)Hypertension, diabetes
Wu C, JAMA Intern Med, 2020 [100]Wuhan20151 (43-60)84 (41.8%)117 (58.2%)Hypertension, CVD, diabetes
Xie H, Liver Int, 2020 [101]Wuhan7960 (48-66)28 (35.4%)51 (64.6%)Hypertension, CVD, diabetes
Xu YH, medRxiv, 2020 [11]Guangzhou4520 (44.4%)25 (55.6%)Hypertension, CVD, diabetes
Zhang GQ, medRxiv, 2020 [10]Wuhan22155 (39-66.5)55 (24.9%)166 (75.1%)Hypertension, CVD, CKD, CLD, diabetes
Zhang JJ, Allergy, 2020 [102]Wuhan14057 (25-87)58 (41.4%)82 (58.6%)Hypertension, CVD, CKD, CLD, diabetes
Zhao W, medRxiv, 2020 [103]Beijing7720 (26.0%)57 (74.0%)Hypertension, CVD, CKD, diabetes
Zhou Y, medRxiv, 2020 [104]Wuhan377NA117 (31.0%)260 (69.0%)Hypertension, CVD, diabetes

ARDS: acute respiratory distress syndrome; CKD: chronic kidney disease; CLD: chronic liver disease; CVD: cardiovascular disease; NA: not available.