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Research Article

Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis

Table 2

Epidemiological characteristics of cardiac injury in COVID-19 patients.

First author, source, yearLocationNo. of patientsNo. of severe patients (%)No. of patients with ACI (%)Note

Cao J, Clin Infect Dis, 2020 [27]Wuhan10218 (17.6%)15 (14.7%)12 ACI cases from 17 nonsurvivors
3 ACI cases from 85 survivors
Huang C, Lancet, 2020 [5]Wuhan4113 (31.7%)5 (12.2%)4 ACI cases from 13 ICU patients
1 ACI case from 28 ICU patients
Wang D, JAMA, 2020 [6]Wuhan13836 (26.1%)10 (7.3%)8 ACI cases from 36 ICU patients
2 ACI cases from 102 non-ICU patients
Hu L, medRxiv, 2020 [85]Wuhan323172 (53.3%)24 (7.4%)13 ACI cases from 26 critical patients
9 ACI cases from 146 severe patients
2 ACI case from 151 nonsevere patients
Hui H, medRxiv, 2020 [7]Beijing417 (17.1%)4 (9.8%)3 ACI cases from 3 critical patients
1 ACI case from 4 severe patients
Shi S, JAMA Cardiol, 2020 [105]Wuhan416NA82 (19.7%)42 deaths in 82 cases with ACI
15 deaths in 334 cases without ACI
Wan S, J Med Virol, 2020 [97]Chongqing13540 (29.6%)10 (7.4%)2 ACI cases from 40 severe patients
8 ACI cases from 95 mild patients
Wu C, medRxiv, 2020 [8]Wuhan188NA21 (11.2%)15 ICU cases and 6 deaths in the low TnI group (60 patients)
14 ICU cases and 6 deaths in the moderate TnI group (66 patients)
27 ICU cases and 31 deaths in the high TnI group (62 patients)
Xu YH, medRxiv, 2020 [11]Guangdong4545 (100.0%)10 (22.2%)All 10 ACI cases from 20 patients required intubation
Yang X, Lancet Respir Med, 2020 [9]Wuhan5252 (100.0%)12 (23.1%)9 ACI cases from 32 nonsurvivors
3 ACI cases from 20 survivors
Zhang GQ, medRxiv, 2020 [10]Wuhan22155 (24.9%)17 (7.7%)16 ACI cases from 55 severe patients
1 ACI case from 166 nonsevere patients
Zhao W, medRxiv, 2020 [103]Beijing7720 (26.0%)2 (2.6%)2 ACI cases from 20 severe patients
Zhou F, Lancet, 2020 [12]Wuhan191119 (62.3%)33 (17.3%)32 ACI cases from 54 nonsurvivors
1 ACI case from 137 survivors

ACI: acute cardiac injury; TnI: troponin I.