Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration
Evaluation of sciatic nerve regeneration after 12 w of surgery. (a) Immunofluorescence staining with an anti-NF200 antibody, anti-S100 antibody, and Hoechst 33342 for the nerve fiber, myelination, and nucleus. (b, c) Area ratio of the regenerated axon and myelin (). (d, e) Electrophysiological assessment of the regenerated sciatic nerve (: CC group versus CCIV and Auto groups, : CCIV versus Auto groups). (f, g) Wet weight ratio of the anterior tibialis and gastrocnemius muscles (: CC group versus CCIV and Auto groups, : CCIV versus Auto groups, and : CC and CCIV groups versus and Auto group).
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