Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration
Observation of regenerated nerve fibers using a transmission electron microscope (TEM) at 12 weeks after surgery for rats in CC (chitosan/collagen scaffolds), CCIV (chitosan/collagen scaffolds with loaded IKVAV and VEGF), and Auto groups. (a) Regenerated nerves at the 5 mm sites of the distal sciatic nerve: right images are the magnification of the left red box. (b) Number of myelin sheath layers (: CC group versus CCIV and Auto groups, : CCIV versus Auto groups). (c) Number of myelin sheaths (: CC and CCIV groups versus Auto group). (d) Thickness of myelin sheaths (: CC group versus CCIV and Auto groups, : CCIV versus Auto groups). (e) g-ratio of myelination of the regenerated nerve (: CC group versus CCIV and Auto groups).