Research / 2020 / Article / Fig 5

Research Article

Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates

Figure 5

NIR-II fluorescence imaging of the deep axillary artery in a healthy adult cynomolgus monkey after IV injection of AIE probes. (a–d) Changes in the relative position of the superficial vein on the skin and the deep axillary artery. When we moved the epidermis, the superficial vein was moved accordingly; however, the deep axillary artery remained stationary. The fluorescence imaging parameters: 808 nm laser with a power density of 30 mW cm-2, 1250 nm long-pass filter, 200 ms exposure time using a pixel two-dimensional InGaAs/SWIR camera, and intravenous dose of 2 mg kg-1. (e) Cross-sectional profiles of NIR-II fluorescence imaging of the same axillary artery shown in (a–d) (red arrows indicates the same bifurcation in the axillary artery). (f) Ultrasonic color Doppler imaging of the axillary artery of the cynomolgus monkey, indicating the depth of the same axillary artery at ~1.5 cm (red arrow indicates the same bifurcation in the axillary artery as shown in Figures 4(a)4(d)).
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