Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly
Response of GdNPs-Gal toward GSH. (a) HPLC analysis of 1-Ga, 1-Gal, and GdNPs-Gal before and after incubation with GSH. (b) DLS analysis of GdNPs-Gal (200 μM) following incubation with GSH (10 mM) for 0–50 min. (c) Plots of 1/ versus Gd concentration determine the relaxivities of GdNPs-Gal before (black) and after (red) incubation with GSH (10 mM, 60 min). Inset: -weighted MR images of the following: I: PBS; II: GdNPs-Gal (200 μM); III: ; IV: Dotarem (200 μM). (d) values, (e) fluorescence spectra, and (f) 19F NMR spectra of GdNPs-Gal (200 μM) upon incubation with GSH (10 mM) for 0–60 min. (g) values, (h) fluorescence spectra, and (i) 19F NMR spectra of GdNPs-Gal (200 μM) upon incubation with varying concentrations of GSH for 60 min. The fluorescence spectra of GdNPs-Gal were measured after 1 to 10 dilutions with PBS buffer. Data denote ().
Please note that the Table of Contents page is currently not displaying content. We are working to fix this issue as soon as possible and apologize for the inconvenience.