Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly
Imaging of GSH in cells. (a) Fluorescence imaging of HepG2 or HUVEC cells following incubation with 200 μM GdNPs-Gal, 1-GdNPs, GdNPs-Gal-Ctrl, GdNPs-Gal plus β-Gal (20 mM), or GdNPs-Gal plus NEM (100 μM, 30 min) for 4 h. Scale bars: 20 μM. (b) -weighted MR (up) and fluorescence (down) images of blank HepG2 cell pellets or HepG2 cell pellets after incubation with 200 μM GdNPs-Gal, 1-GdNPs, GdNPs-Gal-Ctrl, or GdNPs-Gal plus NEM (100 μM, 30 min) for 4 h. (c) Quantification of the average fluorescence intensity (red) and percentage signal enhancement (% SE, black) of the HepG2 cell pellets in (b). (d) 19F NMR spectra of HepG2 cell lysates from cell pellets in (b). (e) Quantification of the uptake of Gd of the indicated cell pellets in (b). Data denote ().,.
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