Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly
Monitoring of hepatic GSH recovery in inflammatory mice receiving DEX therapy. (a) Schematic illustration of GdNPs-Gal-assisted MRI of hepatic GSH levels in inflammatory mice receiving DEX therapy. (b) Axial -weighted MR images and (c) average % SE of inflammatory livers in LPS-treated mice on days 0, 1, 3, 5, and 7. The MR images were acquired before (pre) and at 4 h post i.v. injection of GdNPs-Gal (0.1 mmol kg−1). LPS (20 mg kg−1) was i.p. injected into mice on day 0, followed by i.p. injection of DEX (4 mg kg−1) to treat inflammation on the 1st, 2nd, and 3rd days. The MR contrast in livers is shown in pseudo rainbow color for comparison; white arrows in the images indicate the Dotarem (1 mM) solution as the internal standard. (d) Quantification of hepatic GSH concentration before and on days 1, 3, 5, and 7 after LPS treatment, followed by DEX therapy. Data denote (,,,).