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Research Article

Single-Atom Nanozymes Linked Immunosorbent Assay for Sensitive Detection of Aβ 1-40: A Biomarker of Alzheimer’s Disease

Table 1

Reviews of the detection of Aβ 1-40 with different methods.

TechniquesLOD (pg mL−1)Linear range (pg mL−1)Reference

SAN-LISA0.881-2000This work
Electrochemical immunoassay1920-12500[42]
SWV at GCE7 × 105##Nonlinear[43]
Microfluidic droplet2165#NP[44]
EIS2468#43.3-4.33 × 105#[45]
SPR86.6###86.6-865.9#[46]
SWV8.6 × 105#1.772 × 106-8.66 × 106#[47]

SWV: Square Wave Voltammetry; GCE: Glassy Carbon Electrode; SPR: Surface Plasmon Resonance; ECL: Electrochemiluminescence (ECL) immunosensor; EIS: Electrochemical Impedance Spectroscopy. #Value was expressed in nM and converted to pg mL−1. ##Value was expressed in μg mL−1 and converted to pg mL−1. ###Value was expressed in pM and converted to pg mL−1.