Single-Atom Nanozymes Linked Immunosorbent Assay for Sensitive Detection of Aβ 1-40: A Biomarker of Alzheimer’s Disease

Table 1

Reviews of the detection of Aβ 1-40 with different methods.


Techniques	LOD (pg mL⁻¹)	Linear range (pg mL⁻¹)	Reference

SAN-LISA	0.88	1-2000	This work
Electrochemical immunoassay	19	20-12500	[42]
SWV at GCE	7 × 10^5##	Nonlinear	[43]
Microfluidic droplet	2165^#	NP	[44]
EIS	2468^#	43.3-4.33 × 10^5#	[45]
SPR	86.6^###	86.6-865.9^#	[46]
SWV	8.6 × 10^5#	1.772 × 10⁶-8.66 × 10^6#	[47]

SWV: Square Wave Voltammetry; GCE: Glassy Carbon Electrode; SPR: Surface Plasmon Resonance; ECL: Electrochemiluminescence (ECL) immunosensor; EIS: Electrochemical Impedance Spectroscopy. ^#Value was expressed in nM and converted to pg mL⁻¹. ^##Value was expressed in μg mL⁻¹ and converted to pg mL⁻¹. ^###Value was expressed in pM and converted to pg mL⁻¹.