Chemical Mechanisms of Prebiotic Chirality Amplification
Kinetic resolution with asymmetric autoamplification, where A is the substrate, B is the reactant, C is the catalyst, P is the product, and asterisks indicate chiral molecules (a). Oxidative kinetic resolution of secondary alcohols in the presence of chiral Mn catalyst (b). Plots of (blue; experiment: circles, theory: line) and ee (red; experiment: circles, theory: line) vs. substrate (1-p-tolylethanol) conversion (c). Dynamic control of conformationally flexible catalyst’s chirality upon substrate coordination (d). Substrate enantiomeric enrichment in the oxidative kinetic resolution of scalemic (S)-1-phenylethanol in the presence of conformationally flexible Mn catalyst, starting from substrates with differing ee.