Research / 2020 / Article / Tab 4

Review Article

Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community

Table 4

Summary of 2019-nCoV vaccine developments at different stages [239].

Vaccine nameVaccine type/platformDeveloperVaccine nameVaccine type/platformDeveloper

Ad5-nCoVDNA/adenovirus type 5 vectorCanSino Biological Inc., Beijing Institute of BiotechnologyVaxil Bio COVID-19 vaccineProtein subunit/signal peptide combinationsVaxil Bio
INO-4800DNA/DNA plasmid, electroporation deviceInovio PharmaceuticalsCOVID-19S-TrimerProtein subunit/pandemic adjuvant systemClover Biopharmaceuticals Inc./GSK
N/ADNA/S geneTakis/Applied DNA Sciences/EvvivaxN/AProtein subunit/S proteinAJ Vaccine
N/ADNA plasmidZydus CadilaN/AProtein subunit/li-Key peptideGenerex/EpiVax
N/AAd26/MVA boostJanssen Pharmaceutical CompaniesN/AProtein subunit/S proteinEpiVax/Univ. of Georgia
GV-MVA-VLP/vaccineDNA/nonreplicating viral vectorGeoVax/BravoVaxProtein subunit/S protein (baculovirus production)Sanofi Pasteur
ChAdOx-nCoV-19DNA/nonreplicating viral vectorUniversity of OxfordN/AProtein subunit/Full-length protein
Matrix-MTM adjuvant
Novavax
N/ADNA/nonreplicating viral vector, NasoVAX-S geneAltimmuneHeat’s gp96 based vaccine for COVID-19Protein subunit/Heat’s gp96 backbone to express antigen of COVID-19Heat Biologics/Univ. of Miami
N/ADNA/nonreplicating viral vector (Ad5 S)GreffexN/AProtein subunit/molecular clamp stabilized spike proteinUniversity of Queensland/GSK
N/ADNA/nonreplicating viral vector (VAAST); oral vaccine platformVaxart, Inc.N/AProtein subunit/molecular clamp stabilized spike proteinUniversity of Queensland/GSK
N/ADNA vaccine/measles vector (replicating viral vector)Vaxart, Inc.N/AProtein subunit/S1 or RBD proteinBaylor College of Medicine
N/ADNA vaccine/measles vectorInstitute Pasteur/Themis/Univ. of Pittsburg Center for Vaccine ResearchN/AProtein subunit/plant-based coronavirusiBio/CC-Pharming
TNX-1800/COVID-19DNA vaccine/horsepox vaccine platform-S geneTonix Pharma/Southern ResearchN/AProtein subunit/proteinVIDO-InterVac, University of Saskatchewan
mRNA-1273mRNA/novel lipid nanoparticleModerna/NIAIDN/AProtein subunit/proteinUniversity of Saskatchewan
N/AmRNA vaccine/VLP-cocktail (S, M, E, N)/lipid nanoparticleFudan University/Shanghai JiaoTong University/RNACure BiopharmaLive attenuated virusDeoptimized live attenuated vaccinesCodagenix/Serum Institute of India
N/AmRNA vaccine/lipid nanoparticle/S and S-RBD antigenFudan University/Shanghai JiaoTong University/RNACure BiopharmaVLP VaccinePlant-derived VLP/four structural of rotavirus (VP2, VP4, VP6, and VP7)Medicago Inc.
N/AmRNAvaccine/LUNAR®-nanoparticle nonviral delivery systemArcturus/Duke-NUSInactivated VaccineFormalin-inactivated+alum adjuvantedSinovac
BNT162mRNA vaccineBioNTech/Fosun Pharma/PfizerN/AUnknownUniversity of Hong Kong
N/ASelf-amplifying RNA vaccineImperial College LondonN/AUnknown/IPA’s proprietary discovery platformsImmunoPrecise
N/AmRNACureVacN/AUnknownMIGAL Galilee Research Institute
N/AProtein subunit/Drosophila S2 insect cell expression system VLPsExpreS2ionN/AUnknownDoherty Institute
N/AProtein/S proteinWRAIR/USAMRIIDN/AUnknownTulane University

In clinical studies. Preparing for clinical studies. N/A: not available.