Research / 2020 / Article / Fig 3

Review Article

Smart Microneedles for Therapy and Diagnosis

Figure 3

Separable microneedles. (a) Separable microneedles with bubble structures: (i) schematic illustrations of the composition and application of the microneedles; (ii) optical images of bubble-containing microneedles. The scale bars are 500 μm. Reproduced with permission from Ref. [11], copyright 2019, Springer Nature. (b) Effervescent microneedles with separable ability: (i) optical images of the microneedles; (ii) the separation process of effervescent microneedles in PBS solution. The scale bars are 500 μm. Reproduced with permission from Ref. [48], copyright 2019, American Association for the Advancement of Science. (c) Separable microneedles with dissolvable supporting layer: (i) schematic illustrations of the separation process; (ii, iii) histological sections of microneedle tips left inside the tissue. Reproduced with permission from Ref. [32], copyright 2016, American Chemical Society.