Research / 2020 / Article / Fig 8

Review Article

Smart Microneedles for Therapy and Diagnosis

Figure 8

Microneedles for cargo delivery. (a) Microneedles carrying pancreatic β-cell capsules in the supporting layer for insulin delivery: (i) schematic illustrations of insulin release in response to hyperglycemia; (ii–iv) digital image (ii), SEM image (iii), and fluorescence microscopy image (iv) of the microneedle patch. Pancreatic β-cell capsules are stained with calcium AM. The scale bars are 1 cm in (ii) and 500 μm in (iii, iv). Reproduced with permission from Ref. [107], copyright 2016, Wiley-VCH. (b) Microneedles bearing CSC-containing fibrin gel for heart regenerative factor delivery: (i) schematic illustrations of the microneedles applied to injured heart; (ii, iii) SEM image (ii) and fluorescence microscopy image (iii) of the microneedle patch. CSCs are labelled with DiO. Both scale bars are 500 μm. Reproduced with permission from Ref. [108], copyright 2018, American Association for the Advancement of Science. (c) Schematic illustrations of keratin microneedles carrying exosomes and drugs for hair loss therapy. Reproduced with permission from Ref. [110], copyright 2019, American Chemical Society. (d) Schematic illustrations of hollow microneedles delivering CAP and ICI for cancer therapy. Reproduced with permission from Ref. [111], copyright 2020, PNAS.