Research / 2020 / Article / Tab 5

Review Article

Smart Microneedles for Therapy and Diagnosis

Table 5

Application sites of microneedles.

Application siteMicroneedle propertyFunctionRef.

SkinStiffness, swellable ability or porosity, biocompatibilityBiomarker detection[70]
Optional: biomarker capture ability, specificity
Stiffness, suitable delivery speedDrug delivery, vaccination[2, 11, 53, 92]
Optional: protective effect, adhesion, responsiveness, separability, dissolvability, antibacteria, controllability

IntestineBiocompatibility, protective effect, separability or adhesion or dissolvability, biodegradation, suitable delivery speedDrug delivery[93]
Optional: responsiveness, controllability

Blood vesselsBiocompatibility, protective effect, biodegradation, suitable delivery speedDrug delivery[25, 85]
Optional: scaffold function, mesh function, responsiveness, controllability

Ocular tissuesBiocompatibility, separability or transparency or dissolvability, biodegradation, suitable delivery speedDrug delivery[86]
Optional: responsiveness, controllability

Oral mucosaBiocompatibility, protective effect, biodegradation, suitable delivery speedVaccination[112, 113]
Optional: separability, dissolvability, adhesion, responsiveness

Genital tractsBiocompatibility, protective effect, biodegradation, suitable delivery speedVaccination[114]
Optional: separability, dissolvability, adhesion, responsiveness, adjustability

HeartsStiffness, biocompatibility, protective effect, biodegradation, suitable delivery speedDrug delivery[108]
Optional: dissolvability, adhesion, responsiveness, adjustability