Research / 2020 / Article / Fig 5

Review Article

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

Figure 5

Biomedical chemomechanical responsive hydrogel micromotors for cargo delivery and related potential biomedical operations. (a) Transportation (I) and delivery of drugs (II) by the Mg/Pt-PNIPAM Janus hydrogel micromotors using temperature modulation; (III) fluorescent image indicating the release of drugs from the Mg/Pt-PNIPAM hydrogel micromotor (scale bars, 10 μm). Reproduced with permission from ref. [14], Copyright 2014, American Chemical Society. (b) Drug-releasing theragrippers, which capture tissue and deliver drugs activated by a change of temperature and mechanical strain between the PNIPAM-AAc hinges (scale bars, 1 mm). Reproduced with permission from ref. [81], Copyright 2014, Wiley-VCH. (c) TRAP hydrogel micromotor activation (I) powered by the real-time polymerization of a photocurable hydrogel with fibroblast cells (II~V) (scale bar, 200 μm); (IV) bright field image of an individual hydrogel micromotor; (V) fluorescent image of living cells (wavelength 517 nm). Reproduced with permission from ref. [98], Copyright 2019, Wiley-VCH.