Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer
Histopathology and immunofluorescence of orthotopic BC in C57Bl/6 mice. (a) Histopathological (i.e., H&E), (b) apoptosis (i.e., TUNEL), and (c) immunofluorescence (i.e., caspase-3 and Ki-67) analysis of tumor tissue sections after treatment with PBS as a control, free HCPT, NG/HCPT, or R9NG/HCPT. The scale bars in (a), (b), and (c) represent 50 μm. The quantitative analysis of (d) caspase-3 and (e) Ki-67 expression after treatments with different HCPT formulations. Data are presented as (;,).