Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

Scheme of fabricating MA-HA and fibrinogen composite hydrogel, in which EC, SMC, and EC-SMC spheroids are encapsulated and the migration of cells from the cell spheroids into the hydrogels is measured and compared. The fibrinogen is crosslinked by thrombin, and MA-HA molecules having unsaturated carbon double bonds are subsequently crosslinked by UV irradiation under the existence of photoinitiator I2959.