Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy
The growth behaviors of immune cells on the endothelium-mimicking surface. (a) Fluorescence staining images of macrophages on the 316L SS, Hep, NO, and Hep@NO samples. (b) Macrophage gene expression after culture on samples for 24 h and following stimulation with LPS for 6 h. Resulting influence of samples on inflammatory gene expression (TNF-α, IL-6, IL-18, and IL-1β), M1 (CD86 and iNOS) and M2 (CD206, CD163, and IL-10) markers were determined by RT-qPCR. Data exhibited as the () and analyzed using a one-way ANOVA; ,, and compared to 316L SS; #,##, and ### compared to Hep; &,&&, and &&& compared to NO.