Research / 2021 / Article / Fig 1

Research Article

Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule

Figure 1

Structure of metallothionein and its bound polynuclear metal clusters. (a) Human MT-III schematics showing the N-terminal β-domain and C-terminal α-domain. The metals (in orange) and cysteines (in yellow) along the protein backbone (in green) are numbered based on previous studies [9, 17]. (b) Folded α-domain of MT-III with the protein backbone and cysteine side chains, with sulfur in yellow and cadmium ions in gray (PDB 2F5H) [15]. (c) Hexatomic ring structure of the M3S9 cluster (left) found in βMT and M4S11 cluster (right) in αMT.