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Review Article

Low-Temperature Photothermal Therapy: Strategies and Applications

Figure 7

(a) Schematic illustration of the PEG-modified Gd3+-doped WS2 nanoflake-mediated enhancement of RT and PTT under X-ray and NIR light irradiation. Reprinted with permission from Reference [187]. Copyright 2015, American Chemical Society. (b) Synthesis of BCCGH and its application for multimodal imaging and combined PTT and PDT. (c) Confocal images showing the localization of free HPPH and BCCGH in the different organelles of A549 cells. Hoechst 33342 (Hoechst), ER-Tracker Green (ER-Tracker), rhodamine 123 (Rhod-123), LysoTracker Green (LysoTracker), Golgi-Tracker Green (Golgi-Tracker), and cholesterol-polyethylene glycol (PEG)2k-fluorescein isothiocyanate (Chol-PEG-FITC) were adopted to visualize the nucleus, ER, mitochondrion, lysosome, Golgi apparatus, and plasma membrane, respectively. Scale bar: 10 μm. (d) Confocal images of Hoechst- and FITC-labeled γ-H2AX-stained A549 cells after various treatments as indicated. Scale bar: 10 μm. (b–d) Reprinted with permission from Reference [197]. Copyright 2018, American Chemical Society. (e) Scheme illustrating the use of siRNA/Zr-FeP MOF nanoshuttles for multimodal imaging and synergistic low-temperature PTT and PDT. Reprinted with permission from Reference [194]. Copyright 2018, Wiley-VCH.

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