Localized Myocardial Anti-Inflammatory Effects of Temperature-Sensitive Budesonide Nanoparticles during Radiofrequency Catheter Ablation
Characterization of NPs. (a) Scanning electron microscope (SEM) image of P/B-COS NPs. (b) Dynamic light scattering (DLS) size distribution of P/B-COS NPs. (c) Fourier transform infrared spectroscopy (FTIR) of PLGA, COS, and P/B-COS NPs. (d) Hemolysis ratio (%) of red blood cells cultured with P/B NPs at various concentrations. A ratio less than 5% was regarded as no obvious hemolysis (,). (e) The stability of PLGA NPs, P/B NPs, and P/B-COS NPs in phosphate-buffered saline (PBS) during 48 h were characterized by TSI value. (f) Cumulative BUD release of P/B NPs and P/B-COS NPs in PBS at 37°C and 60°C. indicates , indicates , indicates .