Localized Myocardial Anti-Inflammatory Effects of Temperature-Sensitive Budesonide Nanoparticles during Radiofrequency Catheter Ablation
Drug release profile and preliminary safety evaluation. (a) The circulation profile of Cy5-labeled P/B-COS NPs in the blood. Blood was extracted at different time points after the NPs were injected into the tail vein of C57BL/6 mice and imaged under a fluorescence imaging system. The fluorescence intensity at one minute was normalized to be 100%. (b) Serum biochemistry data of mice treated with PBS (G1), free BUD (G2), PLGA NPs (G3), P/B NPs (G4), P-COS NPs (G5), and P/B-COS NPs (G6) (at an equivalent dose of 1 mg/kg BUD), respectively (,). (c) Photos of ablation on rabbit thigh muscle, the white dotted line is a continuous ablation line. (d) P-COS nanoparticles entering the ablation site of rabbits were characterized by fluorescein isothiocyanate (FITC). (e) The concentration of budesonide was calculated by HPLC on and away from the line ( indicates ).