Research / 2022 / Article / Fig 5

Research Article

Localized Myocardial Anti-Inflammatory Effects of Temperature-Sensitive Budesonide Nanoparticles during Radiofrequency Catheter Ablation

Figure 5

Evaluation of anti-inflammatory effect on pig models. (a) Schematic illustration of localized myocardial anti-inflammatory effects of budesonide during radiofrequency catheter ablation. Reversible lesions and inflammatory responses tend to be milder adjacent to the ablation site. (b) Electroanatomical mapping findings in pigs and the gross pathological results of pigs three days after ablation. (c) M-mode echocardiography in pigs showing the LV wall motion of the heart before and three days after ablation. (d) LVEFs were measured by echocardiography before cardiac ablation (baseline) and 3 days afterward (endpoint). The serum concentration of cTnl (e), ACTH (f), and COR (g) immediately after ablation (0 h) and 24 hours/72 hours later. Serum concentration of IL-6 (h), TNF-α (i), IL-10 (j), and CRP (k) at different time after cardiac ablation. All data are presented as . animals per group ().