Research / 2022 / Article / Fig 2

Research Article

Integrated Au-Nanoroded Biosensing and Regulating Platform for Photothermal Therapy of Bradyarrhythmia

Figure 2

Integrated Au-nanoroded biosensing and regulating system. (a) Fabrication of Au-nanoroded device, including ZnO seeding, hydrothermal growth of ZnO nanorod synthesis, conductive layer pattern, and SU-8 layer insulation. (b–d) Scanning electron microscope (SEM) images of a nanoroded device with the ZnO-nanoroded region, Au-coated-nanoroded region, and SU-8 insulating region. Typical SEM images of ZnO nanorods (c) and Au-coated nanorods (d). (e–g) Layout of the device. (e) Overview of the layout showing the electrically 32 conductive recording electrode tracks and 2 conductive reference electrodes (yellow). (f) The enlarged view showing the layout of the nanoroded region (purple) with a diameter of 4 mm and recording sizes at the center of device. (g) μm2 recording electrodes at the SU-8 insulating opening. (h) Optical images showing Au-nanoroded MEA with a 20 μm opening ring. The Au-nanoroded sites are indicated in red box. (i) Schematic of integrated Au-nanoroded biosensing and regulating system including 808 nm He-Ne laser, Au-nanoroded MEA device, and self-developed electrophysiological recording system. (j) Schematic of multichannel Au-nanoroded device and Au-nanorod-induced photothermal effect. (k) Thermal images of the Au-nanoroded electrode array (MEA) and Au-planar MEA showing the temperature change after radiation with a power of 1.5 W/cm2 for 5 min. The maximum temperature of Au-nanoroded MEA is 41.3°C, which is 15.3°C higher than that of edge area. The maximum temperature of Au-planar device is 31.9°C, which is 9.5°C higher than that of edge area.