Integrated Au-Nanoroded Biosensing and Regulating Platform for Photothermal Therapy of Bradyarrhythmia
Photothermal effect on electrophysiological signals of bradyarrhythmia. (a) Typical electrophysiological signal profile of cardiomyocytes cultured on different devices (Au-nanoroded (A), Au-planar (B), Pt-nanoroded (C), and Pt-planar (D)) under different laser irradiations (1.0, 1.5, and 2.0 W/cm2 for 5 min). (b) Continuous electrophysiological signal recordings of cardiomyocyte during the whole photothermal regulating process. (c) Heat map of the firing rate and amplitude of cardiomyocytes under different conditions. (d) Statistical analysis of the firing rate and amplitude of cardiomyocytes cultured on Au-nanoroded device by the photothermal therapy with laser irradiation (1.0, 1.5, and 2.0 W/cm2 for 5 min). The average values of the standard deviations are labeled above the bar (). Significant differences are analyzed by ANOVA. ,.