Integrated Au-Nanoroded Biosensing and Regulating Platform for Photothermal Therapy of Bradyarrhythmia
Optimization of photothermal regulating duration for the bradyarrhythmia model. (a–c) Typical electrophysiological evolution of cardiomyocytes with bradyarrhythmia by 10 min (a), 5 min (b), and 3 min (c) laser irradiation treatment. (d) Statistics of firing rate evolution of cardiomyocytes in the preirradiation, irradiation, and postirradiation stages. (e) Continuous extracellular electrical signal profile of cardiomyocytes cultured by Au-nanoroded MEA before and after the 1.5 W/cm2 laser irradiation. (f) Statistics of the firing rate for a long period of time. (g) Electrical signals of preirradiation and postirradiation from primary rat cardiomyocyte over consecutive two days. (h) Statistical histogram showing the firing rate and amplitude of signals changes from day 1 to day 2. Significant differences are analyzed by ANOVA. ;,.