The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Li01 and Resveratrol in Ameliorating Colitis in Mice
Therapeutic effect of RSV, Li01, and RSV+Li01 on DSS-induced colitis in mice. (a) Chart describing the experimental design in the DSS-induced colitis mouse model. DSS was dissolved in drinking water and fed on the 1st and 4th week. On the 2nd, 3rd, 5th, and 6th week, mice in the experimental groups were orally administrated with PBS (NS), RSV, Li01, or RSV+Li01. (b–d) Body weight changes, spleen weight, and colon length were recorded and analyzed. (e) H&E staining and colonic damage scores for colon tissue of different groups. Scale bars: 100 μm. (f) Expression of claudin, occluding, and ZO-1 in colon tissue evaluated by immunofluorescence. Scale bars, 100 μm. (g) Concentration of proinflammatory and anti-inflammatory cytokines were analyzed in the serum. Data are presented as ,,,,, and for the comparison.