Research / 2022 / Article / Fig 5

Research Article

A Self-Powered Optogenetic System for Implantable Blood Glucose Control

Figure 5

Controlling blood glucose homeostasis using the SOS in a diabetic mouse model. (a) Schematic diagram of hydrogel’s dynamic interaction with optogenetically engineered HEK-293 cells and LED. (b) Photograph of the hydrogel-coated optogenetically engineered HEK-293 cells and LED. (c) Implantation progress of hydrogel-coated optogenetically engineered HEK-293 cells and LED. (d) Photograph of the mice after implantation of the SOS. (e) SEAP production of implanted mice exposed to FRL or kept in dark. (f)–(i) The db/db mice with implants were illuminated with FRL for glucose restoration. (f) shGLP-1 production in the treated or nontreated mice. (g) Blood glucose value in the treated or nontreated mice. (h) Glucose tolerance test of mice implanted with the SOS. (i) Insulin tolerance test of mice implanted with the SOS. . Data are expressed as ; mice. values were calculated by two-tailed unpaired -test.